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Riviciclib hydrochloride

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SI-7121

Riviciclib hydrochloride, >98% (HPLC)

CAS No. : [920113-03-7]

Synonyms : P276-00

IUPAC Name : 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

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Chemical Properites
Mol. Formula :
C21H20ClNO5 • HCl
Mol. Weight :
438.3
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Riviciclib hydrochloride potently inhibits CDK9, CDK4, and CDK1 with low‑nanomolar activity and disrupts both transcriptional and cell‑cycle regulatory pathways. It demonstrates notable antitumor effects, particularly in cisplatin‑resistant cells.

References : Roskoski R. Jr. Pharmacol. Res., 107, 249-275, 2016; Joshi K. S. et al.: Mol. Cancer Ther., 6(3), 918-25, 2007; Joshi K. S. et al.: Mol. Cancer Ther., 6(3), 926-34, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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