RO-082750

SI-7676

RO-082750, >98% (HPLC)

CAS No. : [37854-59-4]

IUPAC Name : 7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : RO-082750 binds NGF with micromolar potency (IC₅₀≈ 1 µM) and selectively disrupts NGF–p75NTR binding relative to TrkA. It also inhibits MSI‑mediated RNA‑binding activity (IC₅₀ = 2.7 µM), giving it a dual mechanistic profile relevant to neurotrophin signaling and RNA‑regulatory pathways.

References : Arkin M. R. et al.: Nat. Rev. Drug Discov., 3(4), 301-17, 2004; Niederhauser O. et al.: J. Neuro. Sci. Res., 61(3), 263-72, 2000; Minuesa G. et al.: Nat. Commun., 10(1), 2691, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.