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Rodatristat ethyl

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SI-6268

Rodatristat ethyl, >98% (HPLC)

CAS No. : [1673571-51-1]

Synonyms : KAR-5585

IUPAC Name : Ethyl (S)-8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate

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Chemical Properites
Mol. Formula :
C29H31ClF3N5O3
Mol. Weight :
590.04
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Rodatristat ethyl is a potent, orally active TPH1 inhibitor that effectively reduces peripheral serotonin production. This reduction in 5‑HT translates into significant attenuation of pulmonary arterial hypertension in preclinical studies.

References : Aiello R. J. et al.: J. Pharmacol. Exp. Ther., 360(2), 267-279, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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