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Rolipram

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SI-5170

Rolipram, >98% (HPLC)

CAS No. : [61413-54-5]

MDL No. : MFCD00270906

Synonyms : (R,S)-Rolipram; SB-95952; ZK-62711

IUPAC Name : 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

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Chemical Properites
Mol. Formula :
C16H21NO3
Mol. Weight :
275.35
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. An anti-inflammatory agent.

References : MacKenzie S. J. et al. Biochem J. 347(Pt 2), 571-8, 2000; Korhonen R. et al.: Br. J. Pharmacol., 169(7), 1525-36, 2013; Shalaby A. M. et al.: J. Pharmacol Pharmacother., 3(2), 132-7, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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