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Roniciclib

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SI-7114

Roniciclib, >98% (HPLC)

CAS No. : [1223498-69-8]

Synonyms : BAY 1000394

IUPAC Name : Cyclopropyl(4-((4-(((2R,3R)-3-hydroxybutan-2-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(imino)-l6-sulfanone

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Chemical Properites
Mol. Formula :
C18H21F3N4O3S
Mol. Weight :
430.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Roniciclib potently inhibits multiple CDKs (CDK1/2/3/4/7/9) with low‑nanomolar activity and is orally active, making it a valuable tool for probing CDK‑dependent cell‑cycle and transcriptional pathways.

References : Siemeister G. et al.: Mol. Cancer Ther., 11(10), 2265-73, 2012; Lucking U. et al.: Med.Chem., 8(7), 1067-85, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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