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RORgamma agonist 1

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SI-6841

RORγ agonist 1, >98% (HPLC)

CAS No. : [2260631-91-0]

IUPAC Name : (R)-2-(4-Chloro-2-(trifluoromethyl)benzyl)-N-(1-(4-(ethylsulfonyl)phenyl)-2-hydroxyethyl)-1-(2-fluoroethyl)-1H-indole-5-carboxamide

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Chemical Properites
Mol. Formula :
C29H27ClF4N2O4S
Mol. Weight :
611.05
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a potent and orally bioavailable RORγ agonist (EC50 = 21 nM) with demonstrated antitumor activity, making it a useful tool compound for cancer immunotherapy and RORγ‑driven biology.

References : Lu B. et al.: J. Med Chem., 64(20), 14983-14996, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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