RORgamma agonist

SI-7436

RORγ agonist, >98% (HPLC)

IUPAC Name : 6-((2-Chloro-6-fluorophenoxy)methyl)-1-((3-(trifluoromethyl)phenyl)sulfonyl)indoline

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : N‑Arylsulfonyl indoline is a novel RORγ agonist chemotype that enhances TH17‑driven immune activation. SAR studies pinpoint a critical linker region as essential for agonist activity, and HDX‑MS confirms ligand‑induced stabilization of RORγ. This scaffold represents a promising lead for RORγ‑based cancer immunotherapy.

References : Doebelin. C. et al.: ChemMedChem., 11, 2607-2620, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.