RORgammat agonist

SI-7439

RORγt agonist, >98% (HPLC)

IUPAC Name : N-(4-((Benzyl(propyl)amino)methyl)phenyl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : A new tertiary amine series was converted from RORγt agonists into potent inverse agonists by enhancing H12 conformational disruption in the RORγt ligand‑binding domain. Linker tuning and rational optimization delivered indole‑based inverse agonists with improved inhibitory activity for targeting RORγt‑driven inflammation.

References : Yang T. et al.: ACS Med. Chem. Lett., 5(1), 65-68, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.