RORgammat inverse agonist

SI-7440

RORγt inverse agonist, >98% (HPLC)

IUPAC Name : N-(3'-Cyano-4'-isobutyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This biaryl amide RORγt agonist features a co‑crystal structure with the RORγt ligand‑binding domain that precisely maps agonist‑driven receptor stabilization. Its structural attributes enabled the design of both short and long inverse agonists, making this compound a key structural reference point for developing next‑generation RORγt modulators.

References : Wang Y, et al.: ACS Med. Chem. Lett., 9(1), 120-124, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.