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Rosiglitazone-d4

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SL-11596

Rosiglitazone-d4, >98%

CAS No. : [1132641-21-4]

Synonyms : BRL-49653-d4

IUPAC Name : 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy-1,1,2,2-d4)benzyl)thiazolidine-2,4-dione

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Chemical Properites
Mol. Formula :
C18H15D4N3O3S
Mol. Weight :
361.45
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Rosiglitazone-d4 is a deuterium-labelled version of Rosiglitazone. This can be used as an analytical labelled reference standard. Rosiglitazone belongs to the thiazolidinedione class of pharmacological agents. Thiazolidinediones function as insulin sensitizers, lowering circulating levels of glucose, fatty acids, and insulin. Their mechanism of action involves binding to peroxisome proliferator-activated receptors (PPARs).

References : Lehmann J. M. et al.: J. Biol Chem., 270(22), 12953-6, 1995; Willson T. M. et al.: J. Med. Chem., 39(3), 665-8, 1996; Thouennon E. et al.: J. Neurochem., 134(3), 463-70, 2015; Majeed Y. et al.: Mol Pharmacol., 79(6), 1023-30, 2011; Ateyya H. et al.: Can. J. Physiol Pharmacol., 96(3), 215-220, 2018; Haoshen F. et al.: Int Immunopharmacol. 97, 107809, 2021; Zehua W. et al.: Cancer Chemother Pharmacol., 85(2), 273-284, 2020; Ren X. et al.: Brain Res Bull., 209, 110918, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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