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Rosuvastatin

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SL-7766

Rosuvastatin, >98%

CAS No. : [287714-41-4]

MDL No. : MFCD18783208

Synonyms : ZD 4522

IUPAC Name : (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

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Chemical Properites
Mol. Formula :
C22H28FN3O6S
Mol. Weight :
481.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Rosuvastatin is a competitive inhibitor of HMG-CoA reductase with an IC50 of 11 nM. It is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

References : Watanabe M. et al.: Bioorg Med Chem., 5(2), 437-44, 1997; Plante I. et al.: J. Pharm Sci., 101(2), 868-78, 2012; Feng P. F. et al.: Mol Pharm.,16(4), 1477-1488, 2019; Carswell C. I. et al.: Rosuvastatin. Drugs 62(14), 2075-85, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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