Runcaciguat

SI-6528

Runcaciguat, >98% (HPLC)

CAS No. : [1402936-61-1]

Synonyms : BAY-1101042

IUPAC Name : (S)-3-(4-chloro-3-((2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanamido)phenyl)-3-cyclopropylpropanoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Runcaciguat is a selective, orally active activator of oxidized/heme‑free sGC that restores cGMP under oxidative stress and shows reno‑ and cardioprotective efficacy in CKD and HFpEF models.

References : Wittrien T. et al.: Biochem. Pharmacol., 232, 116739, 2025; Bénardeau A. et al.: Naunyn Schmiedebergs Arch Pharmacol., 394(12), 2363-2379, 2021; Kraehling J. R. et al.: Int. J. Mol. Sci, 24(17), 13226, 2023; Duh E. J. et. al.: Diabetes, db240739, 2025.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.