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Ruxolitinib M9 metabolite diastereomer 1

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Ruxolitinib M9 metabolite diastereomer 1, >98%

IUPAC Name : 3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(3-oxocyclopentyl)propanenitrile

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Chemical Properites
Mol. Formula :
C17H16N6O
Mol. Weight :
320.36
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a metabolite of Ruxolitinib, which is a potent and selective JAK1/2 inhibitor. Ruxolitinib is used to treat specific blood and bone marrow cancers and immune conditions.

References : Quintas-Cardama A. et al.: Blood 115(15), 3109-3117, 2010; Verstovsek S. et al.: N. Engl. J. Med., 366(9), 799-807, 2012; Harrison C. et al.: N. Engl. J. Med., 366(9), 787-798, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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