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Ryuvidine

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SI-6653

Ryuvidine, >98% (HPLC)

CAS No. : [265312-55-8]

IUPAC Name : 2-Methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione

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Chemical Properites
Mol. Formula :
C15H12N2O2S
Mol. Weight :
284.33
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ryuvidine inhibits SETD8 with sub‑micromolar potency, reducing H4K20me1 levels and blocking DNA synthesis. It also targets CDK4 and KDM5A, supporting its anticancer effects across tumor types such as breast cancer. In addition, Ryuvidine shows therapeutic benefit in arthritis models.

References : Ryu C. K. et al.: Bioorg. Med. Chem. Lett., 10(5), 461-4, 2000; Blum G. et al.: ACS. Chem. Biol., 9(11), 2471-8, 2014; FitzGerald J. et al.: PLoS One, 9(6), e98891, 2014; Ali R. et al.: 10(6), 1303, 2021; Cotti S. et al.: 16, 59-60, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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