(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

SL-10486

(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one, >98%

CAS No. : [1350643-72-9]

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Applications : This is an advanced key intermediate in the synthesis of Duvelisib and related analogs. Duvelisib is an oral inhibitor of phosphatidylinositol 3-kinase (PI3K). Duvelisib is used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma after other treatments have failed.

References : Pillinger G. et al.: Oncotarget., 7(26), 39784-39795, 2016; Gockeritz E. et al.: Int. J. Cancer., 137(9), 2234-42, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.