(S)-(5-Amino-6-(7-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)-1-methyl-1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)boronic acid pinacol ester

SI-2634

(S)-(5-Amino-6-(7-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)-1-methyl-1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)boronic acid pinacol ester, 97%

CAS No. : [1889336-71-3]

IUPAC Name : (S)-tert-Butyl 4-(2-(3-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-yl)-1-methyl-1H-benzo[d]imidazol-7-yl)-2-methylpiperazine-1-carboxylate

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Applications : This is an advanced key intermediate in the preparation of benzimidazole aminopyrazine analogs. A potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor.

References : Han W. et al.: J. Med. Chem., 59(7), 3034-3045, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.