S-777469

SI-7285

S-777469, >98% (HPLC)

CAS No. : [885496-53-7]

IUPAC Name : 1-(6-Ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxamido)cyclohexane-1-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : S‑777469 activates CB₂ with nanomolar affinity (K_i = 36 nM) and robustly inhibits compound 48/80‑induced scratching in mice. By engaging CB₂‑dependent pathways that dampen itch signal transmission, it demonstrates strong antipruritic activity.

References : Odan M. et al.: Bioorg. Med. Chem. Lett., 22(8), 2803-6, 2012; Haruna T. et al.: Pharmacology, 95(1-2), 95-103, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.