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(S)-9-Hydroxyrisperidone

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SL-4901

(S)-9-Hydroxyrisperidone, >98%

CAS No. : [147663-01-2]

Synonyms : (-)-9-Hydroxyrisperidone; 9-(S)-Paliperidone

IUPAC Name : (9S)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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Chemical Properites
Mol. Formula :
C23H27FN4O3
Mol. Weight :
426.49
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an (S)-enantiomer of Paliperidone, active metabolite of Risperidone. It is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

References : Zhu H. J. et al.: Neuropsychopharmacology, 32(4), 757-764, 2007; Yang M. C. et al.: Psychopharmacology (Berl), 217(3), 397-410, 2011; Gass P. et al.: Prog Neuropsychopharmacol Biol Psychiatry, 36(1), 71-77, 2012; Roenker N. L. et al.: Neurosci Lett, 500(3), 167-171, 2011; Dremencov E. et al.: Psychopharmacology (Berl), 194(1), 63-72, 2007; Schwartzer J. J. et al.: Psychopharmacology (Berl), 203(4), 653-63, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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