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(S)-Azelastine

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SL-7923

(S)-Azelastine, >98%

CAS No. : [143228-85-7]

Synonyms : (+)-Azelastine

IUPAC Name : (S)-4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one

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Chemical Properites
Mol. Formula :
C22H24ClN3O
Mol. Weight :
381.90
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (S)-Azelastine is an enantiomer of Azelastine. Both (S)-Azelastine and (R)-Azelastine are active in the context of antihistamine and antiallergic activity. Azelastine is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.

References : Craig L. F.: Expert Rev Clin Immunol., 1(2), 191-201, 2005; Mohamed M. E. et al.: Arch Physiol Biochem., 1-8, 2020; Carlos D. Z. et al.: Pharmacol Res Perspect., 7(6), e00531, 2019; Li Y. et al.: Acta Pharmacol Sin., 1-7, 2020; Shao-Cheng L. et al.: Eur Arch Otorhinolaryngol., 274(2), 845-853, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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