(S)-Frovatriptan hydrochloride

SL-8306

(S)-Frovatriptan hydrochloride, >98%

CAS No. : [158747-01-4]

Synonyms : ent-Frovatriptan; (3S)- (ACI); (S)-(9CI)

IUPAC Name : (S)-3-(Methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide hydrochloride; 1H-Carbazole-6-carboxamide 2,3,4,9-tetrahydro-3-(methylamino) hydrochloride (1:1); 1H-Carbazole-6-carboxamide 2,3,4,9-tetrahydro-3-(methylamino)monohydrochloride

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5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
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Applications : This is an (S)-enantiomer of Frovatriptan, which is a serotonin 5-HT1B/1D receptor agonist. It is a triptan drug for the treatment of migraine headaches and for short term prevention of menstrual migraine. There is no significant difference in the in vivo pharmacological activity or receptor binding affinity between the (S) and (R) enantiomers of Frovatriptan; however, the commercially available drug is the (R) enantiomer, as it is the one that binds effectively to 5-HT1B/1D receptors and has the desired migraine-treating activity. The (S) enantiomer lacks the appropriate affinity for the targeted receptors, making it inactive for migraine therapy.

References : Parsons A. A. et al.: J. Cardiovasc. Pharmacol., 30, 136, 1997; Siow, C. H. et al.: Cephalalgia, 24, 1045, 2004; Poolsup N. et al.: J. Clin. Pharm. Ther., 30, 521, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.