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(S)-Human enteropeptidase-IN-1

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SI-7097

(S)-Human enteropeptidase-IN-1, >98% (HPLC)

CAS No. : [1802891-23-1]

IUPAC Name : (S)-5-(Carboxymethyl)-3-(3-((4-guanidinobenzoyl)oxy)phenyl)-4,5-dihydroisoxazole-5-carboxylic acid

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Chemical Properites
Mol. Formula :
C20H18N4O7
Mol. Weight :
426.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This selectively inhibits enteropeptidase with low‑nanomolar potency and low systemic exposure, acting through a reversible covalent mechanism that extends enzyme inactivation. In DIO rats, it increases fecal protein output and drives robust weight loss, making it valuable for obesity‑related research.

References : Ikeda Z. et al.: J. Med. Chem., 65(12), 8456-8477, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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