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(S)-Laudanosine

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SL-10814

(S)-Laudanosine, >98%

CAS No. : [2688-77-9]

Synonyms : (S)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Properites
Mol. Formula :
C21H27NO4
Mol. Weight :
357.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (S)-Laudanosine is an alkaloid present in poppy plants and represents the (S)-enantiomer of Laudanosine. It exhibits activity on both the central nervous system and the cardiovascular system by inhibiting low-affinity GABA receptors, with an IC50 value of 10 μM, which may lead to adverse effects such as seizures, hypotension, and bradycardia. Furthermore, Laudanosine demonstrates analgesic properties through competitive binding to the opioid Mu-1 receptor (Ki = 2.7 μM).

References : Fodale V. et al.: European Journal of Anaesthesiology, 19(7), 466-473, 2002; Katz Y. et al.: Brain Res., 646(2), 235-41, 1994; Chulia S. et al.: Br. J. Pharmacol., 113(4), 1377-85, 1994; Chapple D. J. et al.: Br. J. Anaesth., 59(2), 218-25, 1987.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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