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(S)-Nimodipine

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SL-11148

(S)-Nimodipine, >98%

CAS No. : [77940-93-3]

Synonyms : (S)-BAY-e 9736

IUPAC Name : 3-Isopropyl 5-(2-methoxyethyl) (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Properites
Mol. Formula :
C21H26N2O7
Mol. Weight :
418.45
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an (S)-enantiomer of Nimodipine, which is an orally active, well-tolerated, light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used in cerebrovascular disorder research. Notably, the (S)-Nimodipine enantiomer exhibits significantly greater potency compared to the (R)-enantiomer. Furthermore, (S)-Nimodipine is approximately twice as effective as a vasorelaxant when compared to the racemic mixture.

References : Langley M. S. et al.: Drugs 37, 669-699, 1989; Marbacher S. et al.: Intensive Care Med. 34(5), 932-938, 2008; Honn K. V. et al.: Clin Exp Metastasis., 2(1), 61-72, 1984.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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