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(S,R)-CFT8634

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SI-7259

(S,R)-CFT8634, >98% (HPLC)

CAS No. : [2704617-95-6]

IUPAC Name : (R)-3-((4-(4-((S)-1-(2,6-Dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl)-3,3-difluoropiperidin-4-yl)piperazin-1-yl)-3-fluorophenyl)amino)piperidine-2,6-dione

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Chemical Properites
Mol. Formula :
C37H45F3N6O5
Mol. Weight :
710.8
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (S,R)-CFT8634 is a selective BRD9‑directed PROTAC composed of a BRD9 ligand, a CRBN ligand, and a difluorinated piperidinyl‑piperazine linker. These components can assemble into the E3 ligase ligand–linker conjugate 142. By promoting CRBN‑dependent ubiquitination and degradation of BRD9, (S,R)-CFT8634 supports research into BRD9‑mediated diseases, including aberrant proliferative states.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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