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(S)-Tersolisib

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SI-7592

(S)-Tersolisib, >98% (HPLC)

CAS No. : [2883540-91-6]

Synonyms : (S)-LY-4064809; (S)-STX-478-101; (S)-STX-478

IUPAC Name : (S)-1-(2-Aminopyrimidin-5-yl)-3-(1-(5,7-difluoro-3-methylbenzofuran-2-yl)-2,2,2-trifluoroethyl)urea

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Chemical Properites
Mol. Formula :
C16H12F5N5O2
Mol. Weight :
401.30
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (S)-Tersolisib represents the (S)‑configured enantiomer of Tersolisib, which selectively targets PI3Kα mutants, suppresses metabolic dysregulation, and drives antitumor activity in PI3Kα‑mutant xenografts. The enantiomer is useful for probing stereochemical contributions to PI3Kα inhibition.

References : Buckbinder L. et al.: Cancer Discov., 13(11), 2432-2447, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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