S1R antagonist

SI-6271

S1R antagonist, >98% (HPLC)

CAS No. : [1353916-16-9]

IUPAC Name : 5-(4-(Tert-butyl)phenyl)-1-methyl-3-(pyrrolidin-1-ylmethyl)-1H-1,2,4-triazole

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent and highly selective sigma‑1 receptor (S1R) antagonist from a triazole‑based series, showing strong S1R affinity, high selectivity over S2R and 87 other targets, and good metabolic stability with slow microsomal clearance. It also demonstrates excellent BBB permeability in rats. In vivo, it shows no acute toxicity and produces significant analgesic effects in both formalin‑induced inflammatory pain and paclitaxel‑induced neuropathic pain models, supporting its promise as a novel S1R‑targeted analgesic for diverse pain conditions.

References : Peng Y. et al.: J. Med. Chem., 64(2), 890-904, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.