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Sacubitril (RS)enantiomer

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Sacubitril (RS)enantiomer, >98%

CAS No. : [761373-05-1]

MDL No. : MFCD28386956

Synonyms : (2R,4S)-Sacubitril enatiomer

IUPAC Name : 4-(((2R,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

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Chemical Properites
Mol. Formula :
C24H29NO5
Mol. Weight :
411.49
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an opposite enantiomer of Sacubitril, which is a potent NEP inhibitor. Sacubitril is a component of the heart failure medicine of LCZ696.

References : Ksander G. M. et al.: J. Med. Chem., 38(10), 1689-700, 1995; Voors A. A. et al.: Expert Opin Investig Drugs 22(8), 1041-1047, 2013; von Lueder T. G. et al. Circ Heart Fail. 8(1), 71-78, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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