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Saquinavir-d9

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SI-5897

Saquinavir-d9, >98% (HPLC)

Isotopic Purity : 98 atom % D

CAS No. : [1356355-11-7]

IUPAC Name : (S)-N1-((2S,3R)-3-hydroxy-4-((3S,4aS,8aS)-3-((2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)carbamoyl)octahydroisoquinolin-2(1H)-yl)-1-phenylbutan-2-yl)-2-(quinoline-2-carboxamido)succinamide

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Chemical Properites
Mol. Formula :
C38H41D9N6O5
Mol. Weight :
679.91
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Saquinavir-d9 is a deuterium labelled version an analog of Saquinavir, which is a protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor for the potential treatment of COVID-19.

References : Donia M. et al.: Cell cycle 10(3), 492 - 499, 2011; Sharon W. et al.: Journal of Acquired Immune Deficiency Syndromes 50(4), 367-374, 2009; Giovannia B. et al.: AIDS 26 (8): 909-919, 2012; Stefanidou M. et al.: Agents Chemother., 56(8): 4381-4390, 2012; Sun Q. et al.: Signal Transduct Target Ther., 6(1), 212, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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