SAR-125844

SI-8045

SAR-125844, >98% (HPLC)

CAS No. : [1116743-46-4]

IUPAC Name : 1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : SAR-125844 is a selective MET kinase inhibitor with low‑nanomolar potency (IC₅₀ = 4.2 nM; Kᵢ = 2.8 nM). It blocks MET‑dependent signaling pathways and displays strong antitumor effects, supporting its use in studies of MET‑mediated tumor progression.

References : Egile C. et al.: Molecular cancer therapeutics, 14(2), 384-394, 2015; Angevin E. et al.: European Journal of Cancer, 87, 131-139, 2017; Ugolini A. et al.: J. Med. Chem., 59(15), 7066-74, 2016; Egile C. et al.: Mol. Cancer Ther., 14(2), 384-94, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.