SAR-405

SI-7759

SAR-405, >98% (HPLC)

CAS No. : [1523406-39-4]

IUPAC Name : (S)-9-((5-Chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : SAR-405 potently and selectively inhibits the class III PI3K Vps34 (IC₅₀= 1.2 nM; K_d = 1.5 nM) in an ATP‑competitive manner. It blocks autophagy induced by starvation or mTOR inhibition and shows anticancer effects, making it a valuable tool for probing Vps34‑regulated trafficking and survival pathways.

References : Ronan B. et al.: Nat. Chem. Biol., 10(12), 1013-9, 2014; Pasquier B. SAR405, Autophagy, 11(4), 725-6, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.