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Saracatinib

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SI-5705

Saracatinib, >98% (HPLC)

CAS No. : [379231-04-6]

MDL No. : MFCD09832698

Synonyms : AZD-0530

IUPAC Name : N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

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Chemical Properites
Mol. Formula :
C27H32ClN5O5
Mol. Weight :
542.03
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Saracatinib is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases.

References : Green T. P. et al.: Mol Oncol., 3(3), 248-261, 2009; Fuse M. A. et al.: Mol Cancer Ther. Mol Cancer Ther., 16(11), 2387-2398, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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