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SB-203580 hydrochloride

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SI-4164

SB-203580 hydrochloride, >98% (HPLC)

CAS No. : [869185-85-3]

MDL No. : MFCD01862622

Synonyms : SB203580 hydrochloride; RWJ 64809 hydrochloride

IUPAC Name : 4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride

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Chemical Properites
Mol. Formula :
C21H16FN3OS . HCl
Mol. Weight :
413.90
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SB-203580 hydrochloride is a widely used p38 MAPK inhibitor with an IC50 of 0.3-0.5 μM. Also it showed more than 100-fold selectivity over Akt (PKB), LCK, and GSK-3β.

References : Kovackova S. et al.: J. Med. Chem., 58(8), 3393-3410, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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