SB-216763

SI-6356

SB-216763, >98% (HPLC)

CAS No. : [280744-09-4]

IUPAC Name : 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : SB-216763 selectively inhibits GSK‑3α and GSK‑3β with equal potency (IC₅₀ = 34.3 nM) through an ATP‑competitive mechanism, providing a robust chemical probe for studying GSK‑3‑dependent cellular processes.

References : Gurrieri et al.: J. Pharmacol. Exp. Ther., 2010; Kirby L. A. et al.: PLoS One, 7(6), e39329, 2012; Wang M. et al.: Bioorg. Med. Chem. Lett., 21(1), 245-9, 2010; Coghlan M. P. et al.: Chem Biol., 7(10), 793-803, 2000; Wang W. et al.: Toxicol. Appl. Pharmacol., 313, 195-203, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.