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SB-265610

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SI-7315

SB-265610, >98% (HPLC)

CAS No. : [211096-49-0]

IUPAC Name : 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d][1,2,3]triazol-7-yl)urea

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Chemical Properites
Mol. Formula :
C14H9BrN6O
Mol. Weight :
357.17
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SB‑265610 functions as a selective, competitive, non‑peptide allosteric inhibitor of CXCR2, suppressing CINC‑1–induced calcium mobilization and neutrophil migration with low‑nanomolar potency. Its pharmacological profile supports its use in CXCR2‑dependent inflammation research.

References : Auten R. L. et al.: J. Pharmacol Exp Ther., 299(1), 90-5, 2001;Milatovic S. et al.: Wound Repair Regen, (3)213-9, 2003; Li Yang et al.: Cancer Cell, 13(1), 23-35, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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