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SB-269652

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SI-4838

SB-269652, >98% (HPLC)

CAS No. : [215802-15-6]

MDL No. : MFCD18910624

Synonyms : SB269652

IUPAC Name : N‑((trans)‑4-(2-(7-Cyano-3,4-dihydroisoquinolin2(1H)‑yl)ethyl)cyclohexyl)‑ 1H‑indole-2-carboxamide

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Chemical Properites
Mol. Formula :
C27H30N4O
Mol. Weight :
426.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SB-269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

References : Shonberg J. et al.: J. Med. Chem., 58(13), 5287-5307, 2015; Kopinathan A. et al.: J. Med. Chem., 62(1), 371-377, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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