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SB-408124 hydrochloride

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SI-5715

SB-408124 hydrochloride, >98% (HPLC)

CAS No. : [1431697-90-3]

MDL No. : MFCD19443231

IUPAC Name : 1-(6,8-Difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea hydrochloride

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Chemical Properites
Mol. Formula :
C19H18F2N4O . HCl
Mol. Weight :
392.83
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 hydrochloride exhibits 50-fold selectivity over OX2 receptor.

References : Langmead C. J. et al.: Br. J. Pharmacol., 141(2), 340-346, 2004; Kis G. K. et al.: Pflugers Arch., 463(4), 531-536, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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