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SC-919

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SI-7064

SC-919, >98% (HPLC)

CAS No. : [2245949-62-4]

Synonyms : LI-2124

IUPAC Name : 4-((3,5-Dichloropyridin-2-yl)oxy)-2'-oxospiro[cyclohexane-1,3'-indoline]-5'-carboxylic acid

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Chemical Properites
Mol. Formula :
C19H16Cl2N2O4
Mol. Weight :
407.25
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SC‑919 potently inhibits IP6K isoforms, particularly IP6K3, and reduces intracellular IP7 production. This leads to suppression of XPR1‑mediated phosphate export, increased intracellular phosphate and ATP, and lowered circulating phosphate levels. Its pharmacological profile makes it a valuable tool for investigating phosphate dysregulation in chronic kidney disease and hyperphosphatemia.

References : Moritoh Y. et al.: Nat. Commun., 12(1), 4847, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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