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SCH-546738

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SI-7156

SCH-546738, >98% (HPLC)

CAS No. : [906805-42-3]

IUPAC Name : (S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-carboxamide

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Chemical Properites
Mol. Formula :
C23H31Cl2N7O
Mol. Weight :
492.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SCH-546738 is an oral, non‑competitive CXCR3 antagonist with exceptional affinity (Ki = 0.4 nM) for the human receptor. Its potency makes it valuable for mechanistic studies of CXCR3‑driven immune responses.

References : Jenh C. H. et al.: B. M. C. Immunol., 13, 2, 2002; Zhang X. et al.: J. Hepatol., 64(1), 160-70, 2016; Yue C. et al.: Cancer Immunol. Res., 3(8), 864-870, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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