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SI-6198

Seclidemstat, >98% (HPLC)

CAS No. : [1423715-37-0]

Synonyms : SP-2577

IUPAC Name : (E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide

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Chemical Properites
Mol. Formula :
C20H23ClN4O4S
Mol. Weight :
450.94
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Seclidemstat is a reversible, noncompetitive LSD1/KDM1A inhibitor with nanomolar potency (Ki = 31 nM; IC50 = 13 nM). It enhances antitumor immune responses in SWI/SNF‑mutant ovarian cancer and exhibits antiviral effects by blocking viral replication and late gene expression. Seclidemstat is also a key tool compound for Ewing sarcoma research.

References : Dai X. J. et al.: J. Med. Chem., 64(5), 2466-2488, 2021; Soldi R. et al.: PLoS One, 15(7), e0235705, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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