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SEL-120-34A

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SI-7803

SEL-120-34A, >98% (HPLC)

CAS No. : [1609522-33-9]

Synonyms : RVU-120

IUPAC Name : 7,8-Dibromo-9-methyl-2-(piperazin-1-yl)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline

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Chemical Properites
Mol. Formula :
C15H18Br2N4
Mol. Weight :
414.15
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SEL-120‑34A potently and selectively inhibits CDK8/CycC and CDK19/CycC with IC50 values of 4.4 nM and 10.4 nM, respectively. As an orally active ATP‑competitive inhibitor, it effectively modulates Mediator‑associated transcriptional signaling and shows clear antitumor efficacy.

References : Rzymski T. et al.: Oncotarget., 8(20), 33779-33795, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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