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Seladelpar sodium salt

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SI-6102

Seladelpar sodium salt, >98% (HPLC)

CAS No. : [3026272-26-1]

Synonyms : RWJ-800025 sodium salt; MBX-8025 sodium salt

IUPAC Name : Sodium (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate

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Chemical Properites
Mol. Formula :
C21H22F3NaO5S
Mol. Weight :
466.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Seladelpar sodium salt activates PPARδ with an EC50 of 2 nM and shows remarkable selectivity over PPARα and PPARγ. This pharmacological profile makes it a valuable tool for investigating PPARδ‑regulated pathways in primary biliary cholangitis.

References : Sahebkar A. et al.: Expert. Opin. Pharmacother., 15(4), 493-503, 2014; Bays H. E.: et al.: J. Clin. Endocrinol. Metab., 96(9), 2889-97, 2011; Choi Y. J. et al.: Atherosclerosis., 220(2), 470-6, 2012; Haczeyni F. et al.: Hepatol. Commun., 1(7), 663-674, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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