Selitrectinib

SI-7364

Selitrectinib, >98% (HPLC)

CAS No. : [2097002-61-2]

Synonyms : LOXO-195

IUPAC Name : (13E,14E,22R,6R)-35-Fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Selitrectinib is a next‑generation inhibitor of TRK kinases, demonstrating sub‑nanomolar potency toward TRKA (IC₅₀ = 0.6 nM) and strong activity against TRKC (IC₅₀ < 2.5 nM). Its potency and selectivity make it valuable for investigating TRK‑dependent cancers, including those resistant to first‑generation TRK inhibitors.

References : Drilon A. et al.: Cancer Discov., 7(9), 963-972, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.