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Senexin-B

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SI-7802

Senexin-B, >98% (HPLC)

CAS No. : [1449228-40-3]

Synonyms : SNX2-1-165; BCD-115

IUPAC Name : 4-((2-(6-(4-Methylpiperazine-1-carbonyl)naphthalen-2-yl)ethyl)amino)quinazoline-6-carbonitrile

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Chemical Properites
Mol. Formula :
C27H26N6O
Mol. Weight :
450.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Senexin-B potently inhibits CDK8 and CDK19 with Kd values of 140 nM and 80 nM, respectively, and displays excellent aqueous solubility and bioavailability. These characteristics make it a valuable tool compound for probing CDK8/19‑dependent transcriptional pathways.

References : McDermott M. S. et al.: Oncotarget., 8(8), 12558-12575, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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