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SGC-6870

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SI-6165

SGC-6870, >98% (HPLC)

CAS No. : [2561471-27-8]

IUPAC Name : (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

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Chemical Properites
Mol. Formula :
C23H21BrN2O2S
Mol. Weight :
469.4
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SGC-6870 is a selective allosteric PRMT6 inhibitor with strong cellular activity (IC50 = 77 nM). As a chemical probe, it enables targeted investigation of PRMT6 biology and arginine‑methylation signaling.

References : Shen Y. et al. : J. Med.Chem., 64(7), 3697-3706, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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