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Silmitasertib sodium salt

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SI-6476

Silmitasertib sodium salt, >98% (HPLC)

CAS No. : [1309357-15-0]

Synonyms : CX-4945 sodium salt

IUPAC Name : Sodium 5-((3-chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylate

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Chemical Properites
Mol. Formula :
C19H11ClN3NaO2
Mol. Weight :
371.76
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Silmitasertib sodium salt is a potent, orally bioavailable CK2 inhibitor with low‑nanomolar activity (IC50 = 1 nM for CK2α/α′). It effectively blocks CK2‑dependent signaling processes implicated in tumor growth and cellular proliferation.

References : Siddiqui-Jain A. et al.: Cancer Res., 70(24), 10288-98, 2010; Buontempo F. et al.: Oncotarget., 7(2), 1323-40, 2016; Chon H. J. et al.: Front Pharmacol., 6, 70, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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