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Siponimod cholesteryl ester

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Siponimod cholesteryl ester, >98%

Synonyms : Siponimod M17 metabolite

IUPAC Name : (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 1-(4-((E)-1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylate

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Chemical Properites
Mol. Formula :
C56H79F3N2O3
Mol. Weight :
885.25
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a metabolite of Siponimod, which is an orally administered, selective modulator of sphingosine-1-phosphate (S1P) receptors. Siponimod is used in research focused on multiple sclerosis (MS).

References : Gergely P. et al.: Br. J. Pharmacol., 167(5), 1035-47, 2012; Pan S. et al.: ACS Med Chem Lett., 4(3), 333-7, 2013; McGinley M. et al.: Ther Adv Neurol Disord. 2018 Jul 17;11, 1756286418788013, 2018; Behrangi N. et al.: Cells, 8(1):24, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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