Siremadlin

SI-6497

Siremadlin, >98% (HPLC)

CAS No. : [1448867-41-1]

Synonyms : NVP-HDM-201; HDM-201

IUPAC Name : (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Siremadlin selectively disrupts the p53–MDM2 interaction with high potency and demonstrates strong oral bioavailability. Its specificity toward MDM2 enables robust reactivation of p53‑dependent pathways in preclinical cancer models.

References : Chapeau E. A. et al.: Proc. Natl. Acad. Sci., U S A, 114(12), 3151-3156, 2017; Furet P. et al.: Bioorg Med. Chem. Lett., 26(19), 4837-41, 2016; Stéphane F. et al.: American Association for Cancer Research., 16-20, 2016, New Orleans, LA. Philadelphia (PA), AACR. Cancer Res, 76(14), 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.