Siremadlin succinate

SI-6498

Siremadlin succinate, >98% (HPLC)

CAS No. : [1638193-48-2]

Synonyms : NVP-HDM-201 succinate; HDM-201 succinate

IUPAC Name : (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one succinate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Siremadlin succinate selectively targets the MDM2–p53 interface, blocking p53 recognition and preventing its ubiquitination. By stabilizing and activating p53 in wild‑type cells, it functions as a cell‑cycle regulator with relevance to cutaneous melanoma models.

References : Wu C. E. et al.: Br. J. Cancer, 118(4), 495-508, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.