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SJ-000557733

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SI-8098

SJ-000557733, >98% (HPLC)

CAS No. : [1424799-20-1]

Synonyms : (+)-SJ-733

IUPAC Name : (3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(pyridin-3-yl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

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Chemical Properites
Mol. Formula :
C24H16F4N4O2
Mol. Weight :
468.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SJ-000557733 functions as an antimalarial agent by inhibiting PfATP4, the parasite’s Na⁺‑ATPase, thereby disrupting sodium homeostasis and compromising parasite viability.

References : Jimenez-Diaz M. B. et al.: Proc. Natl. Acad. Sci. U. S. A., 111(50), E5455-62, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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