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SKLB-4771

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SI-6339

SKLB-4771, >98% (HPLC)

CAS No. : [1370256-78-2]

Synonyms : FLT3-​IN-​1

IUPAC Name : 1-(5-((7-(3-Morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea

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Chemical Properites
Mol. Formula :
C25H27N7O3S2
Mol. Weight :
537.66
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : SKLB-4771 selectively inhibits FLT3 at low‑nanomolar potency and blocks downstream STAT5 and ERK activation. It reduces tumor‑cell growth and promotes apoptosis, making it valuable for investigating FLT3‑mediated oncogenic pathways.

References : Li W. W. et al.: J. Med. Chem., 55(8), 3852-66, 2012; Yan H. X. et al.: Immunol. Res., 60(1), 112-26, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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